MAO-A
Monoamine oxidase A (MAO-A) is a mitochondrial flavin-dependent enzyme that catalyzes the oxidative deamination of monoamine neurotransmitters and thereby regulates neurotransmitter homeostasis in the nervous system and peripheral tissues[1]. Mechanistically, MAO-A metabolizes serotonin and norepinephrine and contributes to dopamine turnover, generating aldehydes, ammonia, and hydrogen peroxide as metabolic by-products that influence cellular redox status and downstream biological responses[1][2]. Through its control of monoamine catabolism, MAO-A participates in neuropsychiatric and neurodegenerative pathways and has therefore become an important molecular target in neuroscience and drug discovery research[2][3]. In disease-related experimental systems, altered MAO activity has been associated with oxidative stress and tissue dysfunction, while pharmacological inhibition of MAO can modify neurotransmitter metabolism and related physiological outcomes[2][4]. Compared with the closely related isoform MAO-B, MAO-A shows higher substrate preference for serotonin and norepinephrine, whereas MAO-B preferentially metabolizes phenylethylamine and contributes differently to monoamine turnover, making isoform selectivity a critical consideration in experimental design and therapeutic development[3][5]. For experimental applications, selective MAO-A inhibitors such as clorgyline and moclobemide are widely used to investigate monoamine signaling, neurotransmitter metabolism, and MAO-dependent biological mechanisms, while reversible and irreversible inhibitor classes provide complementary pharmacological tools for mechanistic studies[4][2].
References:
- [1]. Wang CC, et al. Monoamine oxidases in development. Cell Mol Life Sci. 2013 Feb;70(4):599-630. [Content Brief]
- [2]. Manzoor S, et al. A comprehensive review of monoamine oxidase inhibitors as Anti-Alzheimer's disease agents: A review. Eur J Med Chem. 2020;206:112787.
- [3]. Ribeiro LV, et al. Monoamine Oxidase Inhibitors in Drug Discovery Against Parkinson's Disease: An Update. Pharmaceuticals (Basel). 2025;18(10):1526.
- [4]. Lighezan R, et al. Monoamine oxidase inhibition improves vascular function in mammary arteries from nondiabetic and diabetic patients with coronary heart disease. Can J Physiol Pharmacol. 2016;94(10):1040-1047.
- [5]. Brannan T, et al. In vivo comparison of the effects of inhibition of MAO-A versus MAO-B on striatal L-DOPA and dopamine metabolism. J Neural Transm Park Dis Dement Sect. 1995;10(2-3):79-89. [Content Brief]
All Product Categories
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MAO-A Related Products (139)
Related Products (139)
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MAO Probe 1
0 ImagesCat. No.: HY-D3221CAS No.: 1386860-79-2MAO Probe 1 is a reactive two-photon fluorescent probe capable of crossing the blood-brain barrier, which is used to detect the activity of monoamine oxidases (MAO-A/MAO-B), with Km values of 70 μM (MAO-A) and 75 μM (MAO-B), respectively. IBC 2 (benzo[g]imino-coumarin 2), the enzymatic product of MAO Probe 1, can further specifically bind to and image Aβ plaques, enabling in vivo two-photon co-monitoring of MAO activity and Aβ plaques. MAO Probe 1 can be used in Alzheimer's disease research (IBC 2: Ex/Em = 850 nm/570-620 nm).
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MAO-B-IN-48
0 ImagesCat. No.: HY-175523MAO-B-IN-48 is a selective MAO-B inhibitor (IC50 = 0.09 μM, Ki = 0.02 μM). MAO-B-IN-48 exhibits inhibitory activity against hBChE (IC50 = 1.10 μM, Ki = 0.43 μM) and AChE (IC50 = 0.56 μM, Ki = 0.14 μM). MAO-B-IN-48 suppresses self-induced aggregation of toxic β-amyloid peptides and exerts antioxidant activity, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. MAO-B-IN-48 can be used for the study of Alzheimer's disease (AD).
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MAO A/HSP90-IN-1
0 ImagesCat. No.: HY-155577CAS No.: 2927489-95-8MAO A/HSP90-IN-1 (4-b) is a MAO A/HSP90 dual inhibitor with IC50 value of 1.77 μM and 0.019 μM in Glioblastoma (GBM) GL26 cells and HSP90α, respectively. MAO A/HSP90-IN-1 (4-b) can inhibit MAO A activity, HSP90 binding and the expression of HER2 and phospho-Akt to inhibit the growth of GBM, they also reduce PD-L1 expression, which inhibits T cell activation. MAO A/HSP90-IN-1 (4-b) have potential to inhibit tumor immune escape. MAO A/HSP90-IN-1 (4-b) can be used for brain tumor-related diseases research.
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H77-77
0 ImagesCat. No.: HY-124331CAS No.: 21618-99-5H77-77 is a selective MAO-A inhibitor with blood-brain barrier permeability, exhibiting an IC50 of 7.4 μM against rat MAO-A. H77-77 accumulates via uptake by serotonergic and noradrenergic neurons. H77-77 releases norepinephrine and serotonin from intracellular neuronal storage sites. H77-77 can be used in studies related to neurological disorders.
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Clorgyline hydrochloride (Standard)
0 ImagesSynonyms: M&B 9302 hydrochloride (Standard)Clorgyline hydrochloride (Standard) (M&B 9302 hydrochloride (Standard)) is the analytical standard of Clorgyline hydrochloride (HY-14197A). This product is intended for research and analytical applications. Clorgyline hydrochloride (M&B 9302 hydrochloride) is a selective, irreversible monoamine oxidase A (MAO-A) inhibitor that can cross the blood-brain barrier and exhibits activity against the 5-HT Receptor at very high doses. Clorgyline hydrochloride regulates monoamine neurotransmitter levels, the release of dopamine and acetylcholine, the uptake and effects of Tyramine (HY-W007606), noradrenergic function, circadian locomotor activity rhythms, feeding behavior, and body weight. Clorgyline hydrochloride induces tumor-suppressive transcriptional programs, secretory differentiation, androgen signaling regulation, Bcl-2 expression, and radioprotective effects in non-malignant cells. Clorgyline hydrochloride is used in the research of high-grade prostate cancer, Huntington's disease, major affective disorder, radiation-induced normal tissue toxicity, and obesity.
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Pirlindole lactate
0 ImagesCat. No.: HY-167152CAS No.: 292039-20-4Pirlindole lactate is an orally active, selective and reversible MAO-A inhibitor with an IC50 value of 250 nM. Pirlindole lactate inhibits genomic replication of Enterovirus species B and D, and exhibits moderate activity against enterovirus species A. Pirlindole lactate inhibits MAO-A-mediated monoamine metabolism, promotes adult hippocampal neurogenesis, rescues stress-induced dendritic atrophy of hippocampal granule neurons, reverses behavioral effects associated with chronic mild stress, and also possesses anticonvulsant, analgesic, local anesthetic, hypotensive, antiplatelet aggregation and antispasmodic activities. Pirlindole lactate shows no detectable mutagenic, clastogenic or carcinogenic properties. Pirlindole lactate can be used in research related to depression and enterovirus infections.
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Carnegine hydrochloride
0 ImagesCat. No.: HY-W676530CAS No.: 5852-92-6Carnegine hydrochloride is a fungicide with broad-spectrum antibacterial activity, as well as a stereoselective inhibitor of MAO-A/MAO-B. Carnegine hydrochloride has no antioxidant activity and does not affect cerebral PDE, but it antagonizes the chronotropic effects of adrenaline and noradrenaline at low concentrations and induces tolerance in *Drosophila melanogaster*. Carnegine hydrochloride stimulates respiration, exerts mild spasmolytic and hypotensive effects, inhibits cancer cell respiration, and exhibits central nervous system excitatory toxicity and negative chronotropic effects on the cardiovascular system.
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Pirlindole-d4
0 ImagesCat. No.: HY-100679SCAS No.: 1801646-26-3Pirlindole-d4 is the d4-labeled Pirlindole (HY-100679). Pirlindole is an orally active, selective and reversible MAO-A inhibitor with an IC50 value of 250 nM. Pirlindole inhibits genomic replication of Enterovirus species B and D, and exhibits moderate activity against enterovirus species A. Pirlindole inhibits MAO-A-mediated monoamine metabolism, promotes adult hippocampal neurogenesis, rescues stress-induced dendritic atrophy of hippocampal granule neurons, reverses behavioral effects associated with chronic mild stress, and also possesses anticonvulsant, analgesic, local anesthetic, hypotensive, antiplatelet aggregation and antispasmodic activities. Pirlindole shows no detectable mutagenic, clastogenic or carcinogenic properties. Pirlindole can be used in research related to depression and enterovirus infections.
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Tetrindole free base
0 ImagesCat. No.: HY-W676790CAS No.: 170964-67-7Tetrindole free base is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole free base inhibits rat brain mitochondrial MAO A in a competitive manner with a Ki value of 0.4 μM and inhibits MAO B with a Ki of 110 μM. Tetrindole free base has antidepressant activity.
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Pirlindole (Standard)
0 ImagesCat. No.: HY-100679RCAS No.: 60762-57-4Pirlindole (Standard) is the analytical standard of Pirlindole (HY-100679). This product is intended for research and analytical applications. Pirlindole is an orally active, selective and reversible MAO-A inhibitor with an IC50 value of 250 nM. Pirlindole inhibits genomic replication of Enterovirus species B and D, and exhibits moderate activity against enterovirus species A. Pirlindole inhibits MAO-A-mediated monoamine metabolism, promotes adult hippocampal neurogenesis, rescues stress-induced dendritic atrophy of hippocampal granule neurons, reverses behavioral effects associated with chronic mild stress, and also possesses anticonvulsant, analgesic, local anesthetic, hypotensive, antiplatelet aggregation and antispasmodic activities. Pirlindole shows no detectable mutagenic, clastogenic or carcinogenic properties. Pirlindole can be used in research related to depression and enterovirus infections.
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Tedizolid phosphate sodium
0 ImagesCat. No.: HY-105041CAS No.: 856867-39-5Synonyms: TR-701FA sodium
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MD 220661
0 ImagesCat. No.: HY-124885CAS No.: 73423-35-5MD 220661 is a semicarbazide-sensitive amine oxidase (SSAO) and monoamine oxidase (MAO) inhibitor, and serves as a major metabolite of MD 240928 in rat brain. MD 220661 acts as a substrate for SSAO and exhibits reversible, selective MAO-B inhibition in rat tissues; in the absence of semicarbazide, its inhibitory potency against MAO-A activity decreases with prolonged pre-incubation time. MD 220661 is applicable to studies related to enzyme-catalyzed metabolism.
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Brofaromine hydrochloride
0 ImagesCat. No.: HY-105127CAS No.: 63638-90-4Synonyms: CGP 11305A hydrochlorideBrofaromine (hydrochloride) is a monoamine oxidase A (MAO-A) inhibitor and a 5-HT uptake inhibitor. Brofaromine (hydrochloride) shows antidepressant-like activity in the social conflict test in rats.
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Pirlindole hydrochloride
0 ImagesCat. No.: HY-W279140CAS No.: 16154-78-2Synonyms: Pyrazidole hydrochloride; Pirazidole hydrochloridePirlindole hydrochloride is an orally active, selective and reversible MAO-A inhibitor with an IC50 value of 250 nM. Pirlindole hydrochloride inhibits genomic replication of Enterovirus species B and D, and exhibits moderate activity against enterovirus species A. Pirlindole hydrochloride inhibits MAO-A-mediated monoamine metabolism, promotes adult hippocampal neurogenesis, rescues stress-induced dendritic atrophy of hippocampal granule neurons, reverses behavioral effects associated with chronic mild stress, and also possesses anticonvulsant, analgesic, local anesthetic, hypotensive, antiplatelet aggregation and antispasmodic activities. Pirlindole hydrochloride shows no detectable mutagenic, clastogenic or carcinogenic properties. Pirlindole hydrochloride can be used in research related to depression and enterovirus infections.
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Acacetin 7-O-(6-O-malonylglucoside)
0 ImagesCat. No.: HY-N13041CAS No.: 155049-92-6Acacetin 7-O-(6-O-malonylglucoside) is a monoamine oxidase inhibitor with strong inhibitory effects on monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) with IC50 values of 2.34 and 1.87 μM, respectively. Acacetin 7-O-(6-O-malonylglucoside) is a reversible MAO inhibitor that can be used in the research of neurodegenerative diseases and affective disorders.
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MAO-B-IN-57
0 ImagesCat. No.: HY-183437CAS No.: 1522345-35-2MAO-B-IN-57 is a selective MAO-B inhibitor with an IC50 of 41.38 nM against human MAO-B. MAO-B-IN-57 shows no significant in vitro cytotoxicity and can significantly increase the survival rate of PC12 cells damaged by 6-OHDA. MAO-B-IN-57 can be used in studies related to Parkinson's disease.
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6,7-Dimethylisatin
0 ImagesCat. No.: HY-W029600CAS No.: 20205-43-06,7-Dimethylisatin (compound 1l), an Isatin (HY-Y0265) analogue, is a potent MAO inhibitor with IC50s of 20.3 μM and 6.74 μM for MAO-A and MAO-B, respectively. 6,7-Dimethylisatin has the potential for depression, Alzheimer's disease and Parkinson's disease research.
